Mode of Action
Fluconazole is a highly selective inhibitor of fungal cytochrome P450 sterol C14-alpha demethylation. This leads to accumulation of 14-alpha methyl sterols resulting in fungistatic activity.
Adve
Central nervous system: Headache
Central nervous system: Dizziness
Gastrointestinal: Nausea, vomiting, abdominal pain, dysgeusia, dyspepsia
Dermatologic: Skin rash
Frequency not defined:
Hepatitis, increased serum alkaline phosphatase, increased serum aspartate aminotransferase, increased serum transaminases, jaundice
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